pI: 5.8822 |
Length (AA): 206 |
MW (Da): 23317 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 168 | 1xoy (A) | 1 | 160 | 33.00 | 0 | 1 | 1.21 | -1.14 |
9 | 168 | 1xoy (A) | 1 | 160 | 32.00 | 0 | 1 | 1.1261 | -1.1 |
13 | 197 | 1wwy (A) | 1 | 171 | 30.00 | 0 | 1 | 1.04346 | -0.33 |
24 | 156 | 1wwy (A) | 12 | 153 | 33.00 | 0.000085 | 1 | 0.869251 | 0.34 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Oocyst, Ring, Sporozoite. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, gametocyte, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Female Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 48 hs, merozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, Male Gametocyte. | Otto TD Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_128642)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G25950 | hypothetical protein |
Babesia bovis | BBOV_III004570 | conserved hypothetical protein |
Brugia malayi | Bm1_44930 | HT014 |
Candida albicans | CaO19.8523 | weak similarity to Neurospora NCU06751.1 and to Drosophila CG6153 gene product |
Candida albicans | CaO19.904 | weak similarity to Neurospora NCU06751.1 and to Drosophila CG6153 gene product |
Caenorhabditis elegans | CELE_ZK353.9 | Protein ZK353.9 |
Cryptosporidium hominis | Chro.10412 | hypothetical protein |
Cryptosporidium parvum | cgd1_3660 | hypothetical protein |
Dictyostelium discoideum | DDB_G0277951 | UPF0424 family protein |
Drosophila melanogaster | Dmel_CG6153 | CG6153 gene product from transcript CG6153-RC |
Echinococcus granulosus | EgrG_000617170 | PITH domain containing protein 1 |
Echinococcus multilocularis | EmuJ_000617170 | PITH domain containing protein 1 |
Homo sapiens | ENSG00000057757 | PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 |
Leishmania braziliensis | LbrM.12.0030 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_120020.1 | PITH domain-containing protein |
Leishmania major | LmjF.12.0020 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.12.0020 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_10117 | HT014 |
Mus musculus | ENSMUSG00000028669 | PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 |
Neospora caninum | NCLIV_042480 | hypothetical protein, conserved |
Oryza sativa | 4324678 | Os01g0559000 |
Plasmodium berghei | PBANKA_1345000 | thioredoxin, putative |
Plasmodium falciparum | PF3D7_1330000 | thioredoxin, putative |
Plasmodium knowlesi | PKNH_1270400 | thioredoxin, putative |
Plasmodium vivax | PVX_082440 | hypothetical protein, conserved |
Plasmodium yoelii | PY04179 | expressed protein |
Schistosoma japonicum | Sjp_0034490 | similar to UPF0424 protein GA19395, putative |
Schistosoma mansoni | Smp_088390 | hypothetical protein |
Schmidtea mediterranea | mk4.064225.00 | |
Trypanosoma brucei gambiense | Tbg972.6.980 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.1270 | PITH domain-containing protein |
Trypanosoma cruzi | TcCLB.509429.100 | PITH domain-containing protein |
Trypanosoma cruzi | TcCLB.507603.30 | PITH domain-containing protein |
Toxoplasma gondii | TGME49_290260 | thioredoxin family Trp26 protein |
Theileria parva | TP02_0813 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.1270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.1270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.1270 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.1270 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_290260 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Pfal004233; Recombinant protein: full-length; Source: P falciparum; hypothetical protein, conserved ; |